Molecular Hematology, 3rd Edition

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Format: eBook
Pub. Date: 2010-01-01
Publisher(s): Wiley-Blackwell
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Summary

Now in its third edition, Molecular Hematology has been thoroughly updated to incorporate recent advances in molecular research. The aim of the book remains the same - to provide a core knowledge base for those with little exposure to molecular biological techniques.Molecular biology has had a significant impact on the understanding of blood diseases and this book shows how molecular techniques can be used in diagnosis and treatment. In each chapter the authors summarize the impact made by molecular research on the understanding of the pathogenesis of the disorder featured, and highlight the molecular strategies that exist, or are being currently investigated, for therapeutic purposes. There are six brand new chapters in this edition: History and development of molecular biology Pharmacogenomics Anemia of chronic disease Molecular pathogenesis of malaria Molecular basis of transplantation Cancer stem cellsPresented in an extremely readable style with clear two-color line diagrams, this book is designed for the non-specialist and will be an invaluable resource for all trainee hematologists.

Table of Contents

List of Contributors
Foreword
Preface
Abbreviations
Beginnings: The Molecular Pathology of Hemoglobin
Molecular cytogenetics and array based genomic analysis
Stem Cells
The Genetics of Acute Myeloid Leukemias
Secondary myelodysplasia/acute myelogenous leukemia - assessment of risk
Detection of Minimal Residual Disease in Hematologic Malignancies
Chronic Myelogenous Leukemia
Myelodysplastic Syndromes
Myeloproliferative Disorders
Lymphoma Genetics
The Molecular Biology of Multiple Myeloma
The Molecular Basis of Anemia
Anemia of chronic disease
Molecular Basis of Iron Metabolism
Hemoglobinopathies due to Structural Mutations
Molecular Pathogenesis of Malaria
Molecular Coagulation and Thrombophilia
The Molecular Basis of Hemophilia
The Molecular basis of von Willebrand Disease
Platelet Disorders
The Molecular Basis of Blood Cell Alloantigens
Functions of Blood Group Antigens
Autoimmune hematologic disorders
Hematopoietic Growth Factors: A 40 Year Journey from Crude "Activities" to Therapeutic Proteins
Molecular Therapeutics in Hematology: Gene Therapy
Pharmacogenomics
Gene expression profiling in the study of lymphoid malignancies
An Introduction to Molecular Biology
Cancer stem cells
Molecular basis of transplant
Index
Table of Contents provided by Publisher. All Rights Reserved.

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