The Pigmentary System Physiology and Pathophysiology

by ; ; ; ; ;
Edition: 2nd
Format: Hardcover
Pub. Date: 2006-05-08
Publisher(s): Wiley-Blackwell
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Summary

The Pigmentary System, Second Edition, gathers into one convenient, all-inclusive volume a wealth of information about the science of pigmentation and all the common and rare clinical disorders that affect skin color. The two parts, physiology (science) and pathophysiology (clinical disorders), are complementary and annotated so that those reading one part can easily refer to relevant sections in the other. For the clinician interested in common or rare pigment disorders or the principles of teaching about such disorders, this book provides an immediate and complete resource on the biologic bases for these disorders. For the scientist studying the biology of melanocyte function, the book provides a list of disorders that are related to basic biological functions of melanocytes.The Pigmentary System contains a completely new section on the basic science of pigmentation - explaining the integration of melanocyte functions with other epidermal cells and with various organ systems like the immune system. There are new chapters on pigmentary disorders related to intestinal diseases, the malignant melanocyte, benign proliferations of melanocytes (nevi) and phototherapy with narrow band UV. All clinical chapters include the latest genetic findings and advances in therapy. Furthermore, there are more than 400 color images of virtually all clinical disorders.The book is ideal for all dermatologists and especially those interested in disorders of pigmentation. It is of particular use for pediatric dermatologists and medical geneticists caring for patients with congenital and genetic pigmentary disorders. This authoritative volume will fill the gap for dermatology training programs that do not have local experts on pigmentation. Basic and cosmetic scientists studying pigmentation and melanocytes will find the science and clinical correlations very useful in showing human significance and relevance to the results of their studies.

Table of Contents

Physiology
Historical and Comparative Perspectives
A History of the Science of Pigmentation
Comparative Anatomy and Physiology of Pigment Cells in Nonmammalian Tissues
The Morphology, Distribution and Biology of the Pigment Cell
General Biology of Mammalian Pigmentation
Extracutaneous Melanocytes
Regulation of Melanoblast Migration and Differentiation
The Biogenesis of Melanosomes
Melanosomal Translocation and Transfer
Regulation of Human Pigmentation by Ultraviolet Light and by Endocrine, Paracrine and Autocrine Hormones
Melanocyte Interactions in the Skin
Growth-GFactor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes
Aging, Replicative Senescence, and the Differentiated Function of the Melanocyte
Advances in Long-Term Maintenance of Normal Human Melanocytes in Culture)
Advances in Immortalization of Cultured Melanocytes and Melanoblasts)
Advances in Melanogenic Assays and Subcellular Fractionation)
Regulation of Melanogenesis by the MSH Receptor
The Molecular Biology of the Pigment Cell
Molecular Approaches to the Study of the Pigment Cell
Piebaldsim, Waardenburg Syndrome, and Related Genetic Disorders - Molecular and Genetic Aspects
Anatomy of Pigment Cell Genes Acting at the Cellular Level
Anatomy of Pigment Cell Genes Acting at the Subcellular Level
Genetic Regulation of the Pigment Cell
Advances in Transgenic Animal Models
Advances in In Vitro Gene Expression
Advances in Gene Mapping
Chemistry and Physics of Melanin and Enzymology of Melanin Synthesis
The Chemistry of Melanins and Related Metabolites
The Physical Properties of Melanins
The Photobiology of the Tanning Response
The Toxicology and Pharmacology of Melanins
The Enzymology of Melanogenesis
Mechanisms of Inhibition of Melanin Pigmentation
Regulation of Melanin Formation
Advances in Chemical Analysis of Melanins
Advances in Physical Analysis of Melanins
Advances in Enzymatic Analysis of Melanogenesis
Pathophysiology
An Overview of Human Skin Color and Its Disorders
The Normal Color of Human Skin
Mechanisms That Cause Abnormal Skin Color
Disorders of Hypopigmentation and Depigmentation
Genetic Hypomelanoses: Disorders Characterized by Congenital Depigmentation
Genetic Hypomelanoses: Disorders Characterized by Acquired Depigmentation
Genetic Hypomelanoses: Disorders Characterized by Generalized Hypomelanoses
Genetic Hypomelanoses: Disorders Characterized by Localized Hypomelanosis
Genetic Hypomelanoses: Disorders Characterized by Hypopigmentation of the Hair
Metabolic, Nutritional, and Endocrine Disorders
Chemical, Pharmacologic and Physical Agents Causing Hypomelanoses
Infectious Hypomelanoses
Inflammatory Hypomelanoses
Neoplastic Hypomelanoses
Miscellaneous Hypomelanoses: Disorders Characterized by Depigmentation
Miscellaneous Hypomelanoses: Disorders Characterized by Hypopigmentation
Miscellaneous Hypomelanoses: Disorders Characterized by Extraneous Loss of Pigmentation
Hypopigmentation Without Hypomelanosis
Disorders of Hyperpigmentation
Genetic Epidermal Syndromes: Disorders Characterized by Generalized Hyperpigmentation
Genetic Epidermal Syndromes: Disorders Characterized by Reticulated Hyperpigmentation
Genetic Epidermal Syndromes: Disorders Characterized by Cafe au Lait Macules
Genetic Epidermal Syndromes: Disorders Characterized by Lentigines
Genetic Epidermal Syndromes: Disorders Characterized by Localised Hyperpigmentation
Genetic Epidermal Syndromes: Disorders of Hyperpigmentation and Premature Aging
Congenital Epidermal Hypermelanoses
Acquired Epidermal Hypermelanoses
Acquired and Congenital Dermal Hypermelanoses
Mixed Epidermal and Dermal Hypermelanoses
Drug-induced or -Related Pigmentation
The Melanocyte System of the Nails and Its Disorders
Table of Contents provided by Publisher. All Rights Reserved.

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